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Roos, Raymond P.

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overview	Dr Roos is the Marjorie and Robert E. Straus Professor in Neurological Science in the Department of Neurology. His research program is focused on the pathogenesis of neurodegenerative diseases, especially amyotrophic lateral sclerosis, and on investigations of picornavirus central nervous system infections. He has published more than 200 papers. Dr. Roos previously served as Chair of the Department of Neurology. He has been a member of the Editorial Boards of the J. Neuroimmunology, J. Neurovirology, J. Virology, and Annals of Neurology, and presently serves on the Editorial Board of Virology and Scientific Reports. He is Associate Editor of Neurology Genetics and Editor-in-Chief of MedLink (an on-line Neurology site). He is a member of the US FDA Cellular, Tissues and Gene Therapies Advisory Committee. He formerly served as Chair of the FDA Transmissible Spongiform Encephalopathies Committee as well as the Chair of the Vaccines and Related Biological Products Advisory Committee. He was a member of the National Academy of Sciences Institute of Medicine Committee to Examine Multiple Sclerosis, American Academy of Neurology Science Committee, Amyotrophic Lateral Sclerosis (ALS) Association grant review committee, National Multiple Sclerosis Society Research Programs Advisory Committee (which he Chaired), and NIH NINDS grant review study section.

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overview

Dr Roos is the Marjorie and Robert E. Straus Professor in Neurological Science in the Department of Neurology. His research program is focused on the pathogenesis of neurodegenerative diseases, especially amyotrophic lateral sclerosis, and on investigations of picornavirus central nervous system infections. He has published more than 200 papers. Dr. Roos previously served as Chair of the Department of Neurology. He has been a member of the Editorial Boards of the J. Neuroimmunology, J. Neurovirology, J. Virology, and Annals of Neurology, and presently serves on the Editorial Board of Virology and Scientific Reports. He is Associate Editor of Neurology Genetics and Editor-in-Chief of MedLink (an on-line Neurology site). He is a member of the US FDA Cellular, Tissues and Gene Therapies Advisory Committee. He formerly served as Chair of the FDA Transmissible Spongiform Encephalopathies Committee as well as the Chair of the Vaccines and Related Biological Products Advisory Committee. He was a member of the National Academy of Sciences Institute of Medicine Committee to Examine Multiple Sclerosis, American Academy of Neurology Science Committee, Amyotrophic Lateral Sclerosis (ALS) Association grant review committee, National Multiple Sclerosis Society Research Programs Advisory Committee (which he Chaired), and NIH NINDS grant review study section.

One or more keywords matched the following items that are connected to Roos, Raymond P.

Item Type	Name
Concept	Acylation
Concept	Action Potentials
Concept	Agglutination
Concept	Algorithms
Concept	Aging
Concept	Alleles
Concept	Amino Acid Sequence
Concept	Antibody Formation
Concept	Axonal Transport
Concept	Antibody Specificity
Concept	Antilymphocyte Serum
Concept	Base Sequence
Concept	Cell Count
Concept	Cell Differentiation
Concept	Cerebrovascular Circulation
Concept	Binding Sites
Concept	beta-Galactosidase
Concept	Brain Chemistry
Concept	Cell Cycle
Concept	Codon
Concept	Genetic Vectors
Concept	Guinea Pigs
Concept	Cross Reactions
Concept	Inclusion Bodies, Viral
Concept	Cytopathogenic Effect, Viral
Concept	Cytotoxicity, Immunologic
Concept	DNA, Recombinant
Concept	Electrophoresis, Polyacrylamide Gel
Concept	Gene Frequency
Concept	Glycoproteins
Concept	Lac Operon
Concept	Exons
Concept	Disease Susceptibility
Concept	Introns
Concept	Enzyme Activation
Concept	Gene Expression Regulation
Concept	Myasthenia Gravis
Concept	Genes, Dominant
Concept	Genes, Viral
Concept	Genetic Techniques
Concept	Glioma
Concept	Glial Fibrillary Acidic Protein
Concept	Freezing
Concept	Gastrostomy
Concept	Nucleic Acid Hybridization
Concept	Genetic Engineering
Concept	Gliosis
Concept	Guanabenz
Concept	Dose-Response Relationship, Drug
Concept	Hydrogen-Ion Concentration
Concept	Immunologic Capping
Concept	Peptide Chain Initiation, Translational
Concept	Immunity, Cellular
Concept	Immunoglobulin gamma-Chains
Concept	G(M1) Ganglioside
Concept	Isoelectric Point
Concept	Illinois
Concept	Molecular Sequence Data
Concept	Pain
Concept	Recombination, Genetic
Concept	Repetitive Sequences, Nucleic Acid
Concept	Mutation
Concept	Nerve Growth Factors
Concept	Neuronal Plasticity
Concept	Synaptic Transmission
Concept	Nucleic Acid Conformation
Concept	Oxidation-Reduction
Concept	Paraguay
Concept	Stress, Physiological
Concept	Polymorphism, Genetic
Concept	Feeding Behavior
Concept	Templates, Genetic
Concept	Plasmids
Concept	Protein Binding
Concept	Protein Conformation
Concept	Protein Processing, Post-Translational
Concept	Genetic Markers
Concept	Hybridization, Genetic
Concept	Glycine
Concept	Haplotypes
Concept	Residence Characteristics
Concept	X-Ray Diffraction
Concept	Species Specificity
Concept	Solubility
Concept	Seasons
Concept	Risk
Concept	Sensitivity and Specificity
Concept	Gerstmann-Straussler-Scheinker Disease
Concept	Time Factors
Concept	Transcription, Genetic
Concept	Protein Biosynthesis
Concept	United States
Concept	Tunisia
Concept	Sequence Homology, Amino Acid
Concept	Virulence
Concept	Virus Replication
Concept	Transduction, Genetic
Concept	Glutamic Acid
Concept	Transforming Growth Factor beta
Concept	HIV Envelope Protein gp120
Concept	Genes, Tumor Suppressor
Concept	Mutagenesis
Concept	Gene Products, tax
Concept	Ion Channel Gating
Concept	Genome, Viral
Concept	Gene Expression
Concept	Genes, pX
Concept	Alternative Splicing
Concept	Protein Structure, Tertiary
Concept	North America
Concept	Consensus Sequence
Concept	Point Mutation
Concept	Gene Transfer Techniques
Concept	Apoptosis
Concept	Sequence Deletion
Concept	Gene Expression Regulation, Developmental
Concept	Oxidative Stress
Concept	Glucose Intolerance
Concept	Transgenes
Concept	Protein Transport
Concept	Mutation, Missense
Concept	Protein Folding
Concept	Heterogeneous-Nuclear Ribonucleoprotein Group A-B
Concept	Endoplasmic Reticulum Stress
Concept	Green Fluorescent Proteins
Concept	Codon, Initiator
Concept	Amino Acid Substitution
Concept	5' Untranslated Regions
Concept	Trinucleotide Repeats
Concept	Active Transport, Cell Nucleus
Concept	Biotinylation
Concept	Nerve Growth Factor
Concept	Glycogen Synthase Kinases
Concept	Glycogen Synthase Kinase 3
Concept	Glutamate Carboxypeptidase II
Concept	Lipoylation
Concept	Unfolded Protein Response
Concept	Vital Capacity
Concept	Temperature
Concept	Down-Regulation
Concept	Protein Multimerization
Concept	Open Reading Frames
Concept	Cell Death
Concept	Transfection
Concept	Gene Expression Regulation, Viral
Concept	Gene Expression Regulation, Enzymologic
Concept	Bacteriophage M13
Concept	Dimerization
Concept	Receptors, Metabotropic Glutamate
Concept	Gene Knockdown Techniques
Concept	MAP Kinase Signaling System
Concept	Protein Sorting Signals
Concept	Immune Evasion
Concept	Protein Stability
Concept	Protein Unfolding
Concept	Antigen-Antibody Reactions
Concept	Canada
Concept	Cell Survival
Concept	Chromosome Aberrations
Concept	Electrophoresis, Agar Gel
Concept	Evoked Potentials
Concept	Genetic Counseling
Concept	Genotype
Concept	Immunity
Concept	Immunity, Innate
Concept	Kinetics
Concept	Genetic Linkage
Concept	Lymphocyte Activation
Concept	Membrane Potentials
Concept	Phenotype
Concept	Translocation, Genetic
Concept	Signal Transduction
Concept	Conserved Sequence
Concept	Penetrance
Concept	Genetic Predisposition to Disease
Concept	Polymorphism, Single Nucleotide
Concept	Muscle Strength
Concept	Biophysical Phenomena
Academic Article	p53 expression induces apoptosis in hippocampal pyramidal neuron cultures.
Academic Article	Construction of a chimeric Theiler's murine encephalomyelitis virus containing the leader gene of foot-and-mouth disease virus.
Academic Article	Molecular characterization of a nondemyelinating variant of Daniel's strain of Theiler's virus isolated from a persistently infected glioma cell line.
Academic Article	Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection.
Academic Article	The regulation of gene expression in neurotrophic viruses.
Academic Article	What happens when mutant neuroserpins get into bad shape.
Academic Article	Molecular determinants for virulence in coxsackievirus B1 infection.
Academic Article	Influence of Theiler's murine encephalomyelitis virus 5' untranslated region on translation and neurovirulence.
Academic Article	Central nervous system cytokine mRNA expression following Theiler's murine encephalomyelitis virus infection.
Academic Article	L* protein of the DA strain of Theiler's murine encephalomyelitis virus is important for virus growth in a murine macrophage-like cell line.
Academic Article	Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage.
Academic Article	A Theiler's virus alternatively initiated protein inhibits the generation of H-2K-restricted virus-specific cytotoxicity.
Academic Article	The role of immunophilins in mutant superoxide dismutase-1linked familial amyotrophic lateral sclerosis.
Academic Article	The prion diseases.
Academic Article	Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
Academic Article	The role of beta-catenin stability in mutant PS1-associated apoptosis.
Academic Article	Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
Academic Article	Novel mutations in spastin gene and absence of correlation with age at onset of symptoms.
Academic Article	Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection.
Academic Article	Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity.
Academic Article	Using a roster and haplotyping is useful in risk assessment for persons with intermediate and reduced penetrance alleles in Huntington disease.
Academic Article	Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA viruses.
Academic Article	Failure to detect poliovirus genetic information in amyotrophic lateral sclerosis.
Academic Article	Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord.
Academic Article	Polyclonal IgM anti-GM1 ganglioside antibody in patients with motor neuron disease and variants.
Academic Article	Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models.
Academic Article	Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse.
Academic Article	Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.
Academic Article	Polyprotein processing of Theiler's murine encephalomyelitis virus.
Academic Article	Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice.
Academic Article	Strains from both Theiler's virus subgroups encode a determinant for demyelination.
Academic Article	Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology.
Academic Article	Restricted heterogeneity of antibody to gp120 and p24 in AIDS.
Academic Article	A subgenomic segment of Theiler's murine encephalomyelitis virus RNA causes demyelination.
Academic Article	Genetically controlled resistance to virus infections of the central nervous system.
Academic Article	Restriction of measles virus gene expression in measles inclusion body encephalitis.
Academic Article	Oligoclonal IgG in rabbits with experimental allergic encephalomyelitis: non-reactivity of the bands with sensitizing neural antigens.
Academic Article	Autosomal dominant cerebrovascular amyloidosis: properties of peripheral blood lymphocytes.
Academic Article	Human immunodeficiency virus gp120 and p24 oligoclonal antibody in acquired immunodeficiency syndrome cerebrospinal fluid and sera.
Academic Article	Mutant SOD1 forms ion channel: implications for ALS pathophysiology.
Academic Article	Characterization and specificity of humoral immune responses to Theiler's murine encephalomyelitis virus capsid proteins.
Academic Article	Immunoglobulin studies in patients with psychiatric diseases.
Academic Article	Detection of visna virus antigens and RNA in glial cells in foci of demyelination.
Academic Article	Relationship of Theiler's murine encephalomyelitis viruses to the cardiovirus genus of picornaviruses.
Academic Article	Oligoclonal IgG bands in cerebrospinal fluid and serum during asymptomatic human immunodeficiency virus infection.
Academic Article	B-cell abnormalities in multiple sclerosis. A hypothesis.
Academic Article	Neuropathy accompanying IgM lambda monoclonal gammopathy.
Academic Article	Neurovirulence determinants of genetically engineered Theiler viruses.
Academic Article	Comparison of agar gel electrophoresis and isoelectric focusing in multiple sclerosis and subacute sclerosing panencephalitis.
Academic Article	Cerebrospinal fluid and serum oligoclonal IgG bands in rabbits with experiment allergic encephalomyelitis.
Academic Article	Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth factor.
Academic Article	Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses.
Academic Article	Immunoperoxidase staining of cerebrospinal fluid IgG in isoelectric focusing gels: a sensitive new technique.
Academic Article	Silver staining of cerebrospinal fluid IgG in isoelectric focusing gels.
Academic Article	First experimental transmission of fatal familial insomnia.
Academic Article	Theiler's virus as a vector for foreign gene delivery.
Academic Article	Selective knockdown of mutant SOD1 in Schwann cells ameliorates disease in G85R mutant SOD1 transgenic mice.
Academic Article	Regulation of excitatory transmission at hippocampal synapses by calbindin D28k.
Academic Article	A single amino acid change determines persistence of a chimeric Theiler's virus.
Academic Article	Familial spastic paraparesis syndrome associated with HTLV-I infection.
Academic Article	Intracerebral distribution of infectious amyloid protein in spongiform encephalopathy.
Academic Article	The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis.
Academic Article	Isoelectric focusing studies of serum and cerebrospinal fluid in patients with antecedent poliomyelitis.
Academic Article	GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity.
Academic Article	Viral infectious complementary-DNA studies may identify nonviral genes critical to central nervous system disease.
Academic Article	Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.
Academic Article	The unfolded protein response in familial amyotrophic lateral sclerosis.
Academic Article	Impaired glucose tolerance and metabolic syndrome in idiopathic polyneuropathy: the role of pain and depression.
Academic Article	Linkage analysis in familial amyotrophic lateral sclerosis.
Academic Article	Nucleic acid probes in the study of amyotrophic lateral sclerosis.
Academic Article	Molecular determinants of Theiler's murine encephalomyelitis-induced disease.
Academic Article	Circulating immune complexes in neurologic disease.
Academic Article	Search for retrovirus in patients with multiple sclerosis.
Academic Article	Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis.
Academic Article	Involvement of cardiovirus leader in host cell-restricted virus expression.
Academic Article	Adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats.
Academic Article	No correlation between aggregates of Cu/Zn superoxide dismutase and cell death in familial amyotrophic lateral sclerosis.
Academic Article	Wrinkles and folds of the prion protein.
Academic Article	Mutant SOD1 knockdown in all cell types ameliorates disease in G85R SOD1 mice with a limited additional effect over knockdown restricted to motor neurons.
Academic Article	An isoelectric focusing study in herpes simplex virus encephalitis.
Academic Article	Analysis of Theiler's virus isolates from persistently infected mouse nervous tissue.
Academic Article	CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses.
Academic Article	Single chain variable fragment antibodies block aggregation and toxicity induced by familial ALS-linked mutant forms of SOD1.
Academic Article	Guanabenz, which enhances the unfolded protein response, ameliorates mutant SOD1-induced amyotrophic lateral sclerosis.
Academic Article	An enhanced integrated stress response ameliorates mutant SOD1-induced ALS.
Academic Article	Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function.
Academic Article	D. CARLETON GAJDUSEK.
Academic Article	Gastrostomy tube placement is safe in advanced amyotrophic lateral sclerosis.
Academic Article	Genetic linkage studies in Huntington disease.
Academic Article	2016 in Review and Message from the Editors to our Reviewers.
Academic Article	TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics.
Academic Article	2017 Year in Review and Message from the Editors to Our Reviewers.
Academic Article	Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice.
Academic Article	2018: Year in Review and Message from the Editors to Our Reviewers.
Grant	Combating stress in G85R ALS mice
Academic Article	Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.
Academic Article	Neurology: Genetics Year in Review.
Academic Article	A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation.
Concept	Machine Learning
Concept	Gene Editing
Concept	Protein Aggregation, Pathological

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